Table 2.

Results of meta-analysis performed on several outcome (TRYCATs) variables with combined different media and separately.

Outcome Feature Sets	n	Groups	SMD	95% CI	z	p	Q	df	p	I2 (%)	τ2	Τ
TRP	29	Overall	−0.517	−0.735; −0.299	−4.650	<0.0001	226.434	28	<0.0001	87.634	0.282	0.531
TRP/CAAs #	7	Melancholia	−0.617	−0.957; −0.277	−3.557	<0.0001	10.435	6	0.107	42.500	0.086	0.293
CAAs #	5	Overall	−0.304	−0.674; 0.066	−1.612	0.107	6.676	4	0.154	40.086	0.070	0.264
KYN/TRP *	17	Overall	−0.032	−0.193; 0.003	−1.896	0.058	107.82	16	<0.0001	85.161	0.170	0.614
	3	Melancholia	−0.095	−0.193; 0.003	−1.896	0.058	0.714	2	0.700	0.000	0.000	0.000
	4	Psychotic	0.224	0.012; 0.436	2.068	0.039	3	3	0.392	0.000	0.000	0.000
	10	Suicidal	0.112	−0.119; 0.055	−0.720	0.471	93.734	9	<0.0001	90.398	0.377	0.614
KYN	17	Overall	−0.114	−0.352; 0.152	−0.935	0.350	126.513	16	<0.0001	87.353	0.203	0.450
KA/KYN *	14	Overall	−0.035	−0.117; 0.048	−0.824	0.410	26.181	13	0.016	50.346	0.028	0.167
	2	Melancholia	0.049	−0.050; 0.148	0.969	0.333	0.402	1	0.526	0.000	0.000	0.000
	5	Psychotic	−0.201	−0.416; 0.013	−1.838	0.066	0.912	4	0.923	0.000	0.000	0.000
	7	Suicidal	−0.231	−0.432; −0.030	−2.256	0.024	13.104	6	0.041	54.213	0.039	0.198
(KYN + 3HK + 3HA + XA + QA + PA)	26	Overall	0.048	−0.189; 0.284	0.396	0.692	209.842	25	<0.0001	89.086	0.295	0.543
KA	13	Overall	−0.260	−0.487; −0.034	−2.258	0.024	67.574	12	<0.0001	82.242	0.125	0.354
AA	3	Overall	−0.248	−0.485; −0.011	−2.055	0.040	2.115	2	0.347	5.432	0.003	0.051
QA	14	Overall	0.358	0.015; 0.701	2.044	0.041	134.272	13	<0.0001	90.318	0.343	0.585

* Significant difference between melancholia, psychotic feature and suicidal behavior. # The effect size was pooled from only melancholia. TRP: tryptophan. KYN: kynurenine. KA: kynurenic acid. 3HK: 3-Hydroxykynurenine. 3HA: 3-Hydroxyanthranilic acid. XA: xanthurenic acid. QA: quinolinic acid. PA: picolinic acid. AA: anthranilic acid. CAAs: competing amino acids (valine + phenylalanine + tyrosine + leucine + isoleucine).