Table 1.

PCs-EV cargo under normal and stimulated conditions.

Source of PC-EVs	Culture Condition	PC-EV Cargo	Beneficial or Adverse Effect	Reference
PC-EVs from retinal PCs	Normal	CTGF, CD44	Protected lung tissue and improved pulmonary function EVs protected VEC function	[47]
	Hypoxia	circEhmt1	Protected endothelial cells from HG-induced injury	[48]
	Diabetic and non-diabetic mouse	cPWWP2A	Controlled diabetes mellitus-induced microvascular dysfunction	[49]
PC-EVs in brain	Stimulated with PDGF-BB	BDNF, bFGF, BNGF, VEGF, PLGF	EV release of BDNF, bFGF, bNGF, VEGF, PLGF Neuroprotection, angiogenesis	[41,46]
	Stimulated with LPS	IL-6, IL-8, IL-10, MCP-1,	Vascular and neuronal inflammation	[41]
PC-EVs in brain	Normal	miR-26a, miR-143, miR 122-5p, miR-6240, miR-122-5p, miR-181a, miR-21, miR-29a, let-7c-5p, let-7a-5p miR-1285	Biomarkers and treatment of hypertension	[43]
PC-EVs in muscle	Stimulation with H2O2	antioxidants and anti-inflammatory compounds	Anti-oxidative Anti-inflammatory Extracellular matrix remodeling	[50]