Table 1.
Literature summary of prognostic role of TANs in CRC.
| Prognosis | First Author | Year | Journal | Model | Keynote | Reference |
|---|---|---|---|---|---|---|
| Better | Chengzeng Yin | 2022 | Oncology Letters | Human | High density of CD66b+ TANs in the invasive margin significantly correlated with better prognoses for OS and DFS of patients with stages I–III CRC. | [54] |
| Xiaowen Xu | 2021 | The Journal of Histochemistry and Cytochemistry | Human | Higher numbers of tumor-infiltrating CD66b+ neutrophils were significantly associated with both longer DFS and OS for CRC patients. | [55] | |
| Juha P Väyrynen | 2020 | Clinical Cancer Research | Human | Intraepithelial TANs and stromal TANs were significantly associated with better CSS and OS, respectively. | [56] | |
| Sofia Edin | 2019 | Scientific Reports | Human | Those highly infiltrated by CD66b+ cells had a significantly improved DSS. | [57] | |
| Lele Ye | 2019 | Frontiers in Immunology | Human | High-CD66b+ TANs were significantly related with better OS and DFS in CRC patients based on GEO and TCGA databases. | [58] | |
| Valeria Governa | 2017 | Clinical Cancer Research | Human | CD66b+ cell infiltration in CRC is significantly associated with increased OS. | [59] | |
| Maria L Wikberg | 2017 | Human Pathology | Human | Infiltration of CD66b+ cells in the tumor front indicated statistically favorable prognoses in patients with stages I–II colon cancer. | [60] | |
| Ryan S Berry | 2017 | PloS ONE | Human | High levels of TANs were associated with improved OS in patients with stage II CRC. | [45] | |
| Maria Rosaria Galdiero | 2016 | International Journal of Cancer | Human | CD66b was found to be a reliable marker to identify TANs in CRC tissues, whereas MPO also identified a subset of CD68+ macrophages. Higher TAN density was associated with better prognosis. | [46] | |
| Raoul A Droeser | 2013 | PloS One | Human | High MPO+ cell infiltration was significantly associated with better prognosis. | [61] | |
| Christian Hirt | 2014 | Oncoimmunology | Human | A high density of MPO+ infiltrating cells was significantly associated with increased 5-year OS. | [62] | |
| Hans Jorgen Nielsen | 1999 | Journal of Pathology | Human | High counts of neutrophils infiltrated in the peritumoral were significant predictors of good OS. | [63] | |
| Worse | Yi Zhang | 2022 | Journal for Immunotherapy of Cancer | Human | The higher proportion of MPO+ cells in tumor-infiltrating stromal cells was significantly associated with worse prognosis. | [64] |
| Katarzyna Jakubowska | 2022 | Oncology Letters | Human | Patients in the low-stroma TAN level group exhibited significantly longer 3- and 5-year DFS rates compared with those in patients in the high-stroma TAN level group. | [48] | |
| Bruce G Rottmann | 2021 | Journal of Clinical Pathology | Human | Patients with neutrophil-rich CRCs showed significantly poorer 5-year RFS compared with patients with neutrophil-intermediate or neutrophil-poor CRCs. | [50] | |
| Hao Su | 2021 | Journal of Cellular and Molecular Medicine | Human | Increased neutrophil infiltration in CRC was associated with a poorer prognosis based on data from GEO and TCGA databases. | [49] | |
| Xiang Hu | 2019 | Frontiers in Oncology | Human | CEACAM8 was used to detect tumor-infiltrating neutrophils within CRC. High-CEACAM8+ tumor-infiltrating neutrophils were associated with worse DFS. | [51] | |
| Yongfu Xiong | 2018 | Cancer Medicine | Human | Tumor-infiltrating neutrophils were significantly associated with poorer prognosis based on data from GEO and TCGA databases. | [65] | |
| Bing Zhu | 2018 | Cancer Medicine | Human | Increased CD66b+ TANs showed statistically unfavorable DFS and OS. | [66] | |
| Yihao Mao | 2018 | Cancer Management and Research | Human | High relative proportion of tumor-infiltrating neutrophils in colon cancer indicated poor OS based on data from GEO and TCGA databases. | [67] | |
| Hui-Lan Rao | 2012 | PloS One | Human | Increased intratumoral CD66b+ neutrophils were correlated with adverse OS. | [47] | |
| No significance | Fang Jian | 2022 | International Immunopharmacology | Human | Tumor-infiltrating neutrophils had no significant effect on the OS of colon adenocarcinoma patients based on TIMER database (p = 0.406). | [52] |
| Zigao Huang | 2021 | Frontiers in Oncology | Human | No significant association was found between tumor-infiltrating neutrophils and survival rates of patients with colon adenocarcinoma based on TIMER database (p = 0.789). | [53] | |
| Y Lin | 2015 | Clinical and Translational Oncology | Human | The number of tumor-infiltrating neutrophils (CD15+ neutrophils) did not significantly affect the overall survival. | [68] | |
| C H Richards | 2012 | British Journal of Cancer | Human | Peritumoral neutrophil infiltration was not significantly associated with CSS (p = 0.27). | [69] | |
| Do Trong Khanh | 2011 | Cancer Science | Human | The infiltration of neutrophils was not significant in predicting either RFS or OS in stages I–III CRCs (p = 0.410/p = 0.080, respectively). | [70] |
OS: overall survival; DFS: disease-free survival; CSS: cancer-specific survival; DSS: disease-specific survival; RFS: recurrence-free survival.