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. 2022 Oct 14;19:257. doi: 10.1186/s12974-022-02619-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TPM1 knockdown elicits inflammation-related transcriptomic alterations and cell death in the TREM2^−/− retina. A, B Ingenuity Pathway Analysis (IPA) of top 20 canonical pathways in WT (A) or TREM2^−/− mice (B) after treatments with LPS and siTPM1-1 or siCTR. p < 0.001. C, D DEGs in the phagosome formation pathway (C) and neuroinflammation signaling pathway (D) in TREM2^−/− mice after treatments with LPS and siTPM1-1 or siCTR. E, F, TUNEL staining (E) and quantification of TUNEL-positive cells (F) in TREM2^−/− mice following treatments with PBS, or with LPS and siTPM1-1 or siCTR. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to PBS or LPS + siCTR, *p < 0.05, **p < 0.01, ***p < 0.001). n = 4 mice in each group. G, H qPCR analysis of Bax and Caspase-3 in TREM2^−/− mouse retinas after treatments with LPS and siTPM1-1 or siCTR. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to PBS or LPS + siCTR, *p < 0.05, ***p < 0.001, ****p < 0.001). n = 5 mice in each group