Table 3.
Summary of analysis on PINT2 regarding patient preference of s.c. versus i.v. trastuzumab.
| Parameter | Category | Thigh N = 110 N (%) |
Abdominal wall N = 109 N (%) |
Overall N = 219 N (%) |
p-value |
|---|---|---|---|---|---|
| In how far were irritations around the s.c. injection site a problem for you? | very | 2 (2.2) | 0 (0.0) | 2 (1.1) | 0.033 |
| a bit | 23 (24.7) | 11 (12.4) | 34 (18.7) | ||
| never | 68 (73.1) | 78 (87.6) | 146 (80.2) | ||
| missing | 17 | 20 | 37 | ||
| How often were the reactions a problem for you? | only at the first and/or second administration | 12 (54.5) | 3 (20.0) | 15 (40.5) | 0.036 |
| in most of the administrations | 10 (45.5) | 12 (80.0) | 22 (59.5) | ||
| missing | 88 | 94 | 182 | ||
| How would you generally describe the s.c. administrations? | very uncomfortable | 1 (1.1) | 7 (8.0) | 8 (4.4) | 0.014 |
| a bit uncomfortable | 17 (18.3) | 7 (8.0) | 24 (13.3) | ||
| acceptable | 75 (80.6) | 74 (84.1) | 149 (82.3) | ||
| missing | 17 | 21 | 38 | ||
| Which method of administration caused the least pain? | i.v. | 20 (21.5) | 11 (12.4) | 31 (17.0) | 0.010 |
| s.c. | 19 (20.4) | 36 (40.4) | 55 (30.2) | ||
| no difference | 54 (58.1) | 42 (47.2) | 96 (52.7) | ||
| missing | 17 | 20 | 37 | ||
| Which method of administration caused less pain due to bruises around the injection site? | i.v. | 13 (14.0) | 5 (5.7) | 18 (9.9) | 0.083 |
| s.c. | 9 (9.7) | 15 (17.0) | 24 (13.3) | ||
| no difference | 71 (76.3) | 68 (77.3) | 139 (76.8) | ||
| missing | 17 | 21 | 38 |
s.c., subcutaneous; i.v. intravenous.