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. 2022 Sep 28;13:971313. doi: 10.3389/fendo.2022.971313

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Copyright © 2022 Diaz Lozano, Sork, Stone, Eldh, Cao, Pernemalm, Gabrielsson and Flodström-Tullberg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The whole plasma proteome differs from the plasma-derived EV proteome. Plasma was collected from non-diabetic NOD mice (n = 4). Abundant plasma proteins were removed using an affinity column. Samples (two technical replicates of each) were then subjected to HiRIEF-LC-MS/MS analysis. (A) Principal Component Analysis (PCA) of the proteome of whole plasma samples showing the clustering of the technical replicates (technical replicates are shown in the same color). (B) Venn Diagram of unique and overlapping proteins between whole plasma and qEV proteomes presented as percentages of the total number of proteins identified and absolute numbers. (C, D) Tissue enrichment analysis of both proteomes showing the top 10 most significant tissues in whole plasma and qEV samples, respectively. (E) Top 10 enriched GO terms for cellular components of the whole plasma proteome. The numbers in C-E represent the counts in each term and the enriched GO terms were scored according to a p-value <0.05.