Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Enzalutamide acts on the AR signaling pathway. Enzalutamide binds to the LBD and blockades the AR signaling pathway by blocking the binding of androgens to AR, impeding the AR nuclear translocation, and inhibiting the AR transcriptional activity. AR-FL: full-length androgen receptor; AR-V7: androgen receptor splice variant 7; DHT: dihydrotestosterone. HSP: heat shock proteins.
