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. 2022 Oct 5;14(19):4877. doi: 10.3390/cancers14194877

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Natural/compound drugs affect the transcriptional activity and protein stability of AR-V7 through the HSP family. ARVib, JG98, and C86 promote AR-V7 degradation by inhibiting HSP40/HSP70 axis; bruceantin promotes AR-V7 degradation by directly binding to HSP90 and disrupting the interaction between HSP90 and AR-V7; KRIBB3 promotes the degradation of AR by interacting with HSP27; niclosamide not only inhibits the transcriptional activity of AR-V7 but also promotes the degradation of AR-V7.