Table 3.

Some molecules in patients with CRPC affect the therapeutic effect of ENZ.

Molecule	Therapeutic Effect of ENZ	Mechanism	Reference
KIF15	Decrease	Increase protein binding of USP14 to AR/AR-V7 to prevent degradation of AR/AR-V7 protein.	Gao et al. (2021) [142]
DBC1	Decrease	Enhance DNA binding activity of AR-V7 and inhibit ubiquitination degradation of AR-V7.	Su et al. (2017) [144]
TNC	Increase	Promote AR-V7 transcriptional activity and protein expression.	Rintu Thomas et al. (2022) [148]
STUB1	Decrease	Promote AR-V7 degradation.	Xu et al. (2020) [149] Liu et al. (2018) [86]

Abbreviations: KIF15: kinesin family member 15; DBCI: deleted in breast cancer 1; TNC: Tenascin-C; STUB1: STIP1 homology and U-box containing protein 1.