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. 2022 Oct 3;14(19):4836. doi: 10.3390/cancers14194836

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Western blotting and RT-PCR showed that H3.3K27M regulated the β-catenin/USP1/EZH2 signaling pathway. (A) Representative blots and statistical graph of the H3.3K27M-induced increase in EZH2 activity in U87 and LN229 cells. (B) Representative blots and histograms showing the quantitative analysis of the increase in USP1 protein levels induced by H3.3K27M in U87 and LN229 cells. (C) Quantification of USP1 mRNA levels in U87 and LN229 cells after stable H3.3K27M overexpression. (D) Representative blots and statistical graph of β-catenin and P-β-catenin (Ser675) levels in U87 and LN229 cells. * p < 0.05; ns indicates no statistical significance.