Table 2. Summary of the outcome of the included studies.

Author	All-cause mortality, HR (95% CI)	CV mortality, HR (95% CI)	Primary outcome	Secondary outcome	Study quality, NOS
Ishimura et al. (2007)	2.060a [1.026–4.135]	1.020a [0.323–3.220]	all-cause mortality	CV mortality	9
Markaki et al. (2012)	1.160a [0.340–3.959]	NR	all-cause mortality	NR	7
Vervloet et al. (2013)	NR	1.560a [0.950–2.561]	CV mortality	NR	7
João Matias et al. (2014)	1.149a [1.005–1.314]	1.220a [0.732–2.033]	all-cause and CV mortality	NR	8
Fein et al. (2014)	2.550b [1.398–4.652]	NR	all-cause mortality	NR	9
Lacson et al. (2015)	1.600 [1.303–1.965]	NR	all-cause mortality	NR	8
de Roij van Zuijdewijn et al. (2015)	1.140 [1.013–1.283]	1.370a [1.173–1.600]	all-cause and CV mortality	NR	9
Garagarza et al. (2015)	2.040a [1.508–2.759]	NR	all-cause mortality	NR	6
Kurita et al. (2015)	1.730 [1.201–2.492]	NR	all-cause mortality	NR	7
Li et al. (2015)	1.170a [1.051–1.302]	NR	all-cause mortality	NR	9
Yang et al. (2016)	0.970a [0.814–1.156]	NR	all-cause mortality	NR	9
Cai et al. (2016)	0.075a [0.010–0.557]	0.013a [0.001–0.162]	all-cause and CV mortality	NR	9
Ago et al. (2016)	2.410a [1.461–3.975]	NR	all-cause mortality	NR	7
Selim et al. (2017)	1.140a [0.445–2.922]	NR	all-cause mortality	NR	8
Ye et al. (2018)	1.530a [0.980–2.389]	1.430a [0.799–2.558]	CV mortality	All-cause mortality	8
Wu et al. (2019)	8.300a [4.258–16.181]	NR	all-cause mortality	NR	9
Tamura et al. (2019)	1.550b [1.040–2.310]	1.698b [0.877–3.289]	all-cause mortality	CV mortality	8
Mizuiri et al. (2019)	2.790 [1.831–4.250]	3.730 [2.031–6.849]	all-cause and CV mortality	NR	8
Shimohata et al. (2019)	2.730a [1.072–6.953]	NR	all-cause mortality	NR	7
Mizuiri et al. (2020)	1.720b [1.007–2.939]	NR	all-cause mortality	NR	8
Lu et al. (2020)	3.535 [1.594–7.838]	4.285 [1.422–12.910]	all-cause and CV mortality	NR	7

Notes:

^aAdjust HR.

^bData extracted from Kaplan-Meier survival curve.

Abbreviations: CV, cardiovascular; HR, hazard ratio; NOS, Newcastle-Ottawa Scale; NR, Not reported.