Figure 3.

Doxorubicin response is associated with different baseline microbiome populations. (A) Representative images of In Vivo Imaging System (IVIS) of mice after each dose of doxorubicin injection over 4-week of treatment. (B) Tumor volumes of control untreated and doxorubicin (Dox) only treated group stratified into responder and nonresponder. n = 7–14, **** p < 0.0001. (C) Tumor volume of control untreated group in mm³, n = 7. (D) Tumor volume of Dox responder group in mm³, n = 14. (E). Tumor volume of Dox nonresponder group in mm³. n = 12. (F) Tumor weights in grams. * p = 0.03, ** p = 0.004. Proportional abundance of bacterial species before doxorubicin treatment between responder and nonresponder groups, (G) Roseburia intestinalis, (H) Akkermansia muciniphila, (I) (Clostridium) clostridioforme, (J) (Eubacterium) eligens, (K) Oscillibacter ruminantium, (L) Alistipes putredinis, (M) Enterorhabdus caecimuris. n = 5–6; * p < 0.01, ** p = 0.005, *** p = 0.0003.