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View full-text article in PMC

. 2022 Oct 9;14(19):4942. doi: 10.3390/cancers14194942

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Genetic subclones can have characteristic chromatin landscapes. (A) Genetic subclones coexist in a tumour. Each colour marks cells in a subclone. Subclones can have distinctive epigenetic profiles, represented by the colour of the nuclei. (B) Single-cell or single-nucleus approaches such as ATAC-seq can reveal the differences in chromatin profiles between genetic subclones. (C) Because of their specific chromatin landscape, each subclone can be predisposed to behave like cancer stem cells or not.