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. 2022 Oct 9;14(19):4942. doi: 10.3390/cancers14194942

Table 1.

Epigenetic factors dysregulated in GBM and compounds targeting them.

Epigenetic Factors Tool Compounds Clinically Available Drugs Reference
PRC2/EZH2 UNC1999, GSK343 Tazemetostat [110,111]
DNA methylation 5-Azacytidine, decitabine [116] (review)
WDR5 C16 [126]
Menin/MLL1 MI-2, MI-3 SNDX-5613, KO-539 [128,129,130]
DOT1L Pinometostat [134,135]