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Molecular pathways in the regulation of OP-associated osteoclasts by ferroptosis. 2ME2, the HIF-1α specific inhibitor, induced osteoclast ferroptosis by increasing MDA and Fe2+ content through the RANKL pathway. ARS and its compounds down-regulated the RANKL-induced osteoclast generation pathway and significantly increased TFR1-mediated iron uptake to induce osteoclast ferroptosis.
