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. 2022 Oct 1;14(19):4814. doi: 10.3390/cancers14194814

Figure 1.

Figure 1

(A) Graphic representation of MET exon 13, 14, and 15 sizes, primers for RT-PCR binding sites, and predicted size of wild-type and MET exon 14 PCR products. (B,C) Alamut visual prediction of MET splicing with c.3028+3A>T and c.3012_3028del variants. With the use of four splicing predictors, donor prediction signals, shown with vertical blue bars (each bar corresponded to an individual splicing predictor) at the 5′ donor sites are reduced, suggesting that these variants alter splicing. Vertical green bars are for 3′ acceptor sites showing minimum or no change. Heights of the bars are proportional to splicing strength. Known constitutive signals are displayed as a small blue triangle for 5′ or a green triangle for 3′.