Table 2.

Oral squamous cell carcinoma-related targeted therapeutic molecules and targets.

Drug	Targets	Functions	References
Coronarin D	JNK	Induce JNK phosphorylation and promote apoptosis	[93]
Dehydrocrenatidine	ERK, JNK	Activation of ERK and JNK induces apoptosis.	[92]
Polyphyllin G	ERK, JNK, p38	Activation of ERK, Akt, p38, and JNK induces apoptosis of oral cells.	[87]
Xanthorrhizol	JNK, p38	Caspase-independent apoptosis was induced by ROS-mediated activation of p38MAPK and JNK.	[89]
PCH4	JNK	Induce JNK phosphorylation and promote apoptosis	[90]
Paclitaxel	JNK	Induce JNK phosphorylation and promote apoptosis	[91]
Demethoxycurcumin	JNK, p38	Induce JNK and p38 phosphorylation and promote apoptosis	[120]
Cetuximab	p38	Activation of p38 promotes skin toxicity.	[121]
Tipifarnib	ERK	Induce ERK phosphorylation and promote apoptosis	[117]