Table 5.

Studies of REM sleep in AD mouse models.

Mouse Model Name	Amyloid/Tau Model	Frequency Band (Hz)	Age (months)	Findings	Reference
rTG4510	Tau	N/A	5–10	↓ number of REM bouts at > 6 mo	Holton et al. (2020)
P301S (PS19)	Tau	4–8	3, 6, 9, 11	↓ amount of REM sleep at 9–11 mo ↑ REM theta power at 9 mo ↓ REM theta power at 11 mo	Holth et al. (2017)
J20	Amyloid	5–7	11–12	↓ amount of REM sleep	Filon et al. (2020)
Tg2576	Amyloid	13–20 20–30	12	↑ REM beta power ↑ REM gamma power	Kent et al. (2018)