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. 2022 Sep 21;11(19):2954. doi: 10.3390/cells11192954
Main hypotheses of the review:
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    Cognitive impairment is a common problem after surgery

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    Epigenetic dysregulation may play a role in its development

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    Anesthetics alter expression of DNA and histone-modifying enzymes

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    This causes an altered epigenetic profile of genes involved in neuroinflammation and neuronal maintenance and development

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    Epigenetic drugs may be a novel therapeutic option for the treatment of postoperative cognitive impairment