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. 2022 Sep 28;14(19):4731. doi: 10.3390/cancers14194731

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Tumor budding and PDC grades assessed according to ITBCC recommendations. Tumor buds are indicated by red arrowheads, PDCs by green arrowheads. (A) Bd grade 0 (no tumor bud in the hot spot), (B) Bd grade 1 (1–4 tumor bud/hot spot), (C) Bd grade 2 (5–9 tumor bud/hot spot), (D) Bd grade 3 (≥10 tumor bud/hot spot), (E) PDC grade 0 (no PDC in the hot spot), (F) PDC grade 1 (1–4 PDC/hot spot), (G) PDC grade 2 (5–9 PDC/hot spot), (H) PDC grade 3 (≥10 PDC/hot spot); (PDC: poorly differentiated cluster, original magnification 20×).