Table 3.
Univariable and multivariable survival analyses in the total cohort (pT: Primary tumor extent, pN: Regional lymph node metastasis, pM: Distant metastasis, n.s.: statistically non-significant; Statistically significant p values are displayed in bold).
| Parameter | Total Cohort—Overall Survival | Total Cohort—Disease Free Survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | ||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||
| TB | low/high | 2.3 (1.5–3.3) |
<0.0001 | 1.65 (1.11–2.45) |
0.014 | 2 (1.4–2.8) |
0.0003 | n.s. | n.s. |
| PDC | low/high | 1.4 (0.99–2) |
0.058 | n.s. | n.s. | 1.2 (0.85–1.7) |
0.3 | n.s. | n.s. |
| Sex | M/F | 0.72 (0.54–0.96) |
0.025 | 0.72 (0.54–0.96) |
0.023 | 0.8 (0.61–1.1) |
0.12 | n.s. | n.s. |
| Age | years | 1 (0.99–1) |
0.41 | 1.02 (1.00–1.03) |
0.009 | 1 (0.99–1) |
0.94 | n.s. | n.s. |
| pT | I–II/ III–IV |
2.6 (1.7–4) |
<0.0001 | n.s. | n.s. | 2.7 (1.8–4.1) |
<0.0001 | n.s. | n.s. |
| pN | pN0/pN+ | 3 (2.1–4.2) |
<0.0001 | 2.79 (1.96–3.96) |
<0.0001 | 2.9 (2.1–4) |
<0.0001 | 2.73 (1.96–3.79) |
<0.0001 |
| pM | pM0/pM1 | 2.1 (1.3–3.6) |
0.036 | n.s. | n.s. | 2.6 (1.6–4.2) |
0.0002 | 2.05 (1.24–3.39) |
0.005 |
| Lauren-type | intestinal/ other |
1.1 (0.93–1.4) |
0.23 | n.s. | n.s. | 1.1 (0.91–1.3) |
0.33 | n.s. | n.s. |
| Grade | G1/G2/G3 | 1.2 (0.93–1.6) |
0.16 | n.s. | n.s. | 1.2 (0.89–1.5) |
0.29 | n.s. | n.s. |
| Residual tumor | absent/ present |
2 (1.5–2.8) |
<0.0001 | 1.84 (1.33–2.54) |
0.0002 | 1.9 (1.4–2.6) |
<0.0001 | 1.65 (1.21–2.27) |
0.002 |
| Lymphovascular invasion | absent/ present |
2.1 (1.6–2.8) |
<0.0001 | n.s. | n.s. | 2.1 (1.6–2.7) |
<0.0001 | n.s. | n.s. |
| Perineural invasion | absent/ present |
1.5 (1.1–1.9) |
0.011 | n.s. | n.s. | 1.5 (1.1–2) |
0.0035 | n.s. | n.s. |