Table 4.
Univariable and multivariable survival analyses in the intestinal type adenocarcinomas (pT: Primary tumor extent, pN: Regional lymph node metastasis, pM: Distant metastasis, n.s.: statistically non-significant; Statistically significant p values are displayed in bold).
| Parameter | Intestinal Type—Overall Survival | Intestinal Type—Disease Free Survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | ||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||
| TB | low/high | 2.5 (1.6–4.1) |
0.0001 |
1.99
(1.23–3.22) |
0.005 | 2 (1.3–3.2) |
0.0016 | n.s. | n.s. |
| PDC | low/high | 1.3 (0.84–2) |
0.24 | n.s. | n.s. | 1.1 (0.7–1.6) |
0.78 | n.s. | n.s. |
| Sex | M/F | 0.67 (0.44–1) |
0.058 | n.s. | n.s. | 0.82 (0.55–1.2) |
0.34 | n.s. | n.s. |
| Age | years | 0.99 (0.98–1) |
0.59 | n.s. | n.s. | 0.98 (0.96–1) |
0.07 | n.s. | n.s. |
| pT | I–II/ III–IV |
1.7 (1–2.8) |
0.034 | n.s. | n.s. | 1.8 (1.1–2.9) |
0.013 | n.s. | n.s. |
| pN | pN0/pN+ | 2.6 (1.7–4) |
<0.0001 |
2.40
(1.57–3.66) |
<0.0001 | 2.4 (1.6–3.6) |
<0.0001 |
2.46
(1.65–3.66) |
<0.0001 |
| pM | pM0/pM1 | 2.9 (1.3–6.2) |
0.007 | n.s. | n.s. | 2.3 (1.1–5.1) |
0.03 | n.s. | n.s. |
| Grade | G1/G2/G3 | 1 (0.71–1.4) |
0.96 | n.s. | n.s. | 0.96 (0.69–1.3) |
0.8 | n.s. | n.s. |
| Residual tumor | absent/ present |
2.2 (1.4–3.4) |
0.001 |
2.04
(1.28–3.26) |
0.0028 | 2 (1.2–3.1) |
0.0035 |
2.08
(1.31–3.30) |
0.0018 |
| Lymphovascular invasion | absent/ present |
2.2 (1.5–3.3) |
<0.0001 | n.s. | n.s. | 2.1 (1.5–3.1) |
<0.0001 | n.s. | n.s. |
| Perineural invasion | absent/ present |
1.8 (1.2–2.8) |
0.006 | n.s. | n.s. | 1.9 (1.2–2.8) |
0.0031 | n.s. | n.s. |