Table 5.
Lymph node metastasis prediction (pT: Primary tumor extent, pM: Distant metastasis, n.i.: not included in the analysis /as only intestinal type was analysed in these columns, Lauren type was not included as a variable here/, n.s.: statistically non-significant; Statistically significant p values obtained from multivariable analyses are displayed in bold).
| Parameter | Total Cohort | Intestinal Type | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | ||||||
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
| TB | low/high | 3.65 (2.03–6.62) |
<0.0001 |
2.86
(1.20–6.88) |
0.019 | 2.36 (1.18–4.76) |
0.015 |
2.78
(1.07–7.52) |
0.038 |
| PDC | low/high | 1.61 (0.86–2.98) |
0.132 |
0.37
(0.13–0.99) |
0.057 | 0.94 (0.44–1.94) |
0.860 | n.s. | 0.075 |
| Sex | M/F | 1.12 (0.66–1.93) |
0.68 | n.s. | n.s. | 1.25 (0.62–2.60) |
0.534 | n.s. | n.s. |
| Age | years | 0.98 (0.95–1.00) |
0.051 | n.s. | n.s. | 0.96 (0.92–0.99) |
0.009 |
0.96
(0.92–0.99) |
0.036 |
| pT | I–II/ III–IV |
14.80 (7.20–32.65) |
<0.0001 |
7.19
(3.09–17.75) |
<0.0001 | 7.58 (3.24–19.49) |
<0.0001 |
4.34
(1.65–12.32) |
0.004 |
| pM | pM0/pM1 | 6.52 (1.30–118.59) |
0.071 | n.s. | n.s. | 3.81 (0.63–72.85) |
0.221 | n.s. | n.s. |
| Lauren-type | intestinal/ other |
2.23 (1.42–3.63) |
0.0008 | n.s. | n.s. | n.i. | - | n.i. | - |
| Grade | G1/G2/G3 | 3.23 (1.99–5.35) |
<0.0001 | n.s. | n.s. | 2.02 (1.13–3.69) |
0.019 | n.s. | n.s. |
| Residual tumor | absent/ present |
2.67 (1.34–5.83) |
0.008 | n.s. | n.s. | 1.53 (0.66–3.75) |
0.334 | n.s. | n.s. |
| Lymphovascular invasion | absent/ present |
11.32 (6.24–21.42) |
<0.0001 |
6.09
(3.10–12.30) |
<0.0001 | 7.56 (3.70–16.23) |
<0.0001 |
5.11
(2.30–12.02) |
<0.0001 |
| Perineural invasion | absent/ present |
2.21 (1.19–4.35) |
0.016 | n.s. | n.s. | 3.11 (1.37–7.75) |
0.009 | n.s. | n.s. |