Figure 7.

Disease-associated microglia profile differs between human sCJD and AD. Frontal cortex tissue of a sCJD patient and an age-matched AD patient show reactivity for the pan-microglia/macrophage marker IBA1, the microglial marker TMEM119, and the activation marker CD68 [97]. Deposits of misfolded proteins are shown for the respective antibodies against amyloid-β (AD) or PrP^Sc (sCJD). Note that the deposition pattern of misfolded PrP^Sc may vary considerably between CJD patients (see also Figure 6). In contrast to AD, microglia activation is more prominent and the microglial homeostasis marker is almost completely lost in sCJD [97]. Scale bar: 50 µm.