Table 1.
Demographic Characteristics of the Participants in the Analysis Sample, Stratified According to Cardiovascular Outcome.*
| Characteristic† | Analysis Sample | Fatal Cardiovascular Events | Fatal or Nonfatal Cardiovascular Events‡ | ||
|---|---|---|---|---|---|
| Participants with No Event | Participants with Event | Participants with No Event | Participants with Event | ||
| Participants — no./total no. (%) | 38,589/38,589 (100) | 38,270/38,589 (99.2) | 319/38,589 (0.8) | 19,877/20,656 (96.2) | 779/20,656 (3.8) |
| Sex — no./total no. (%) | |||||
| Male | 19,168/38,589 (49.7) | 18,941/19,168 (98.8) | 227/19,168 (1.2) | 8,972/9,474 (94.7) | 502/9,474 (5.3) |
| Female | 19,421/38,589 (50.3) | 19,329/19,421 (99.5) | 92/19,421 (0.5) | 10,905/11,182 (97.5) | 277/11,182 (2.5) |
| Race — no./total no. (%)§ | |||||
| Black | 5,792/38,589 (15.0) | 5,731/5,792 (98.9) | 61/5,792 (1.1) | 2,486/2,592 (95.9) | 106/2,592 (4.1) |
| White or other than Black orWhite | 32,797/38,589 (85.0) | 32,539/32,797 (99.2) | 258/32,797 (0.8) | 17,391/18,064 (96.3) | 673/18,064 (3.7) |
| Cohort, country, years of childhood visits — no./total no. (%) | |||||
| Bogalusa Heart Study, U.S., 1973–1994 | 11,737/38,589 (30.4) | 11,623/11,737 (99.0) | 114/11,737 (1.0) | 4,058/4,253 (95.4) | 195/4,253 (4.6) |
| Childhood Determinants of Adult Health, AUS, 1985 | 8,426/38,589 (21.8) | 8,414/8,426 (99.9) | 12/8,426 (0.1) | 3,103/3,130 (99.1) | 27/3,130 (0.9) |
| Minnesota Childhood Cardiovascular Cohorts, U.S., 1978–1996 | 2,032/38,589 (5.3) | 2,023/2,032 (99.6) | 9/2,032 (0.4) | 1,218/1,232 (98.9) | 14/1,232 (1.1) |
| Muscatine Study, U.S., 1970–1981 | 9,842/38,589 (25.5) | 9,699/9,842 (98.5) | 143/9,842 (1.5) | 6,577/6,978 (94.3) | 401/6,978 (5.7) |
| NHLBI Growth and Health Study, U.S., 1987–1996 | 820/38,589 (2.1) | 818/820 (99.8) | 2/820 (0.2) | 509/513 (99.2) | 4/513 (0.8) |
| Princeton Lipid Research Study, U.S., 1973–1978 | 2,201/38,589 (5.7) | 2,173/2,201 (98.7) | 28/2,201 (1.3) | 954/1,019 (93.6) | 65/1,019 (6.4) |
| Cardiovascular Risk in Young Finns Study, FIN, 1980–1986 | 3,531/38,589 (9.2) | 3,520/3,531 (99.7) | 11/3,531 (0.3) | 3,458/3,531 (97.9) | 73/3,531 (2.1) |
| Birth year | 1969.6+7.4 | 1969.7+7.4 | 1963.8+6.2 | 1968.3+7.6 | 1963.0+5.9 |
| Mean calendaryearofchildhood visit¶ | 1981.5+6.3 | 1981.5+6.3 | 1976.7+4.8 | 1980.9+6.4 | 1976.3+4.6 |
| Mean age at childhood visits — yr‖ | 11.8+3.1 | 11.8+3.1 | 12.9+2.9 | 12.3+3.1 | 13.3+2.8 |
| Attainable age in 2016 — yr | 46.4+7.4 | 46.3+7.4 | 52.2+6.2 | 47.4+7.6 | 53.0+5.9 |
| Age at time of event — yr** | NA | NA | 47.0+8.0 | NA | 47.1+7.4 |
| Parental education level — no./total no. (%) | |||||
| Less than high school degree | 5,051/23,401 (21.6) | 5,011/5,051 (99.2) | 40/5,051 (0.8) | 3,284/3,397 (96.7) | 113/3,397 (3.3) |
| High school degree | 7,501/23,401 (32.1) | 7,426/7,501 (99.0) | 75/7,501 (1.0) | 4,303/4,504 (95.5) | 201/4,504 (4.5) |
| Higherthan high school degree but no college degree | 5,104/23,401 (21.8) | 5,080/5,104 (99.5) | 24/5,104 (0.5) | 3,261/3,340 (97.6) | 79/3,340 (2.4) |
| College degree or higher | 5,745/23,401 (24.6) | 5,727/5,745 (99.7) | 18/5,745 (0.3) | 3,664/3,728 (98.3) | 64/3,728 (1.7) |
| Participant education level — no./total no. (%) | |||||
| Less than high school degree | 1,469/21,473 (6.8) | 1,460/1,469 (99.4) | 9/1,469 (0.6) | 835/887 (94.1) | 52/887 (5.9) |
| High school degree | 4,952/21,473 (23.1) | 4,910/4,952 (99.2) | 42/4,952 (0.8) | 4,114/4,292 (95.9) | 178/4,292 (4.1) |
| Higher than high school degree but no college degree | 7,088/21,473 (33.0) | 7,074/7,088 (99.8) | 14/7,088 (0.2) | 6,021/6,185 (97.3) | 164/6,185 (2.7) |
| College degree | 5,187/21,473 (24.2) | 5,173/5,187 (99.7) | 14/5,187 (0.3) | 4,495/4,592 (97.9) | 97/4,592 (2.1) |
| Higher than college degree | 2,777/21,473 (12.9) | 2,774/2,777 (99.9) | 3/2,777 (0.1) | 2,501/2,534 (98.7) | 33/2,534 (1.3) |
Plus–minus values are means ±SD. Percentages may not total 100 because of rounding. AUS denotes Australia, FIN Finland, NA not applicable, and NHLBI National Heart, Lung, and Blood Institute.
There were no missing data for birth year, mean calendar year of childhood visits, mean age at childhood visits, or attainable age in 2016.
Data are presented for the 20,656 participants who could be evaluated for fatal or nonfatal cardiovascular events. A comparison between observed and imputed values is provided in Table S26 in Supplementary Appendix 1. Nonfatal cardiovascular events included the first instance of adjudicated myocardial infarction, stroke, transient ischemic attack, ischemic heart failure, angina, peripheral artery disease, carotid intervention, abdominal aortic aneurysm, or coronary revascularization.
Race was reported by the parent and was updated if the participant was seen in adulthood.
The mean calendar year of childhood visits was the mean calendar year across all available childhood visits by the participant from the age of 3 to 19 years.
The mean age at childhood visits was the mean age of the participant across all available childhood visits from the age of 3 to 19 years.
Age at time of event was assessed among 319 participants who had a fatal event and among 779 participants who had a fatal or nonfatal event.