Table 2.

Univariate and multivariate cox proportional hazard regression analysis of the four-gene inflammatory signature (continuous variable), considering overall survival and progression free survival.

		Univariable Analysis		Multivariable Analysis
Overall Survival (OS)		HR (95% CI)	p-Value	HR (95% CI)	p-Value
inflammatory signature	continuous variable	0.66 (0.53–0.79)	0.001	0.65 (0.51–0.82)	<0.001
ECOG PS	1 vs. 0	1.28 (1.08–1.48)	0.213	1.51 (1.02–2.25)	0.041
subsite	oropharynx vs. other	1.52 (1.33–1.72)	0.031	1.58 (1.07–2.34)	0.022
		Univariable analysis		Multivariable analysis
Progression Free Survival (PFS)		HR (95% CI)	p-value	HR (95% CI)	p-value
inflammatory signature	continuous variable	0.57 (0.43–0.72)	<0.001	0.54 (0.4–0.71)	<0.001
ECOG PS	1 vs. 0	1.39 (1.18–1.6)	0.117	1.80 (1.2–2.77)	0.008
subsite	oropharynx vs. other	1.31 (1.1–1.52)	0.193	1.36 (0.9–2.07)	0.146