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. 2022 Sep 21;11(19):2946. doi: 10.3390/cells11192946

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EndoMT in human coronary artery atherosclerosis. Publicly available scRNAseq data from Wirka et al. [30] on unsorted cells from atherosclerotic human coronary arteries were reanalyzed. (a) EC cluster was determined based on the expression of CDH5 and PECAM1 (red oval). (b) Cells from the EC cluster were further analyzed using higher cluster resolution. We observed two clusters, 6 and 8, enriched with EndoMT markers. (c) Interestingly, only cluster 8 had ACTA2⁺ and other SMC contractile marker-positive cells. (d) Cluster 6 was enriched with FN1, collagens, and pro-angiogenesis genes.