Figure 5.

(A) Circle plot showing predicted differential cell–cell communications between severe Delta and Wuhan-like groups (red for gained, and blue for lost in Delta cases). We identified several newly gained communications for the Delta cohort established by Mon IFI30 with MAIT and NK cells and by gdT-cells with MAIT and CD8 Tr cells. (B) Bar plot showing the intensity of context-specific signaling pathways measured as relative information flow as implemented in CellChat. TGF beta and SPP1 are predicted as main signaling molecules involved in cell–cell communication for severe Delta COVID-19 aside from Resistin, CD23, and Caledon. (C) Dot plot showing cell pairs (x-axis) and predicted interacting ligand–receptors (y-axis) for SPP1, TGF beta, and complement pathways. Color on the dot plot shows the strength of a given ligand–receptor interaction quantitatively represented by a probability value obtained with CellChat and calculated based on the law of mass action relying on the average expression of the ligand in a cell group and receptor by another cell group. (D) Chord diagram showing interacting cell types in severe samples via CCL-CXCL axis for severe Wuhan-like samples. (E) Chord diagram showing interacting cell types via CCL-CXCL axis for severe Delta samples.