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Effect of quinacrine upon AA release from fMLP (1 μM)-challenged PMN. PMN were incubated in buffer (open squares) or PDE (closed squares). Results are expressed as mean (± SEM) percent inhibitions relative to control (no quinacrine) (n = 6, six dialysis effluents upon PMN from six donors). Absolute control values (100%) were 1.90% ± 0.22% and 4.80% ± 0.55% total radioactivity incorporated for unprimed and primed cells, respectively.
