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. Author manuscript; available in PMC: 2023 Sep 29.
Published in final edited form as: Cell. 2022 Sep 29;185(20):3807–3822.e12. doi: 10.1016/j.cell.2022.09.015

Figure 2. Primary tumor samples harbor disease-specific mycobiomes, See also Figure S2.

Figure 2.

(A) Principal coordinate analysis (PCoA) of normalized species abundances from head-neck (HNSC), esophageal (ESCA), stomach (STAD), colon (COAD), rectal (READ), lung (LUSC), breast (BRCA), and brain (LGG) reveal clustering by tumor type, after filtering contaminants and false-positive signals.

(B) Clustered heatmap showing difference in relative fungal species abundances (RPM) between tissues from each TCGA cancer type, after filtering. Species are included if classified as tissue-associated in any of GI, lung, or breast samples, even if they were classified as contaminants in others. Heatmap values are z-scored by species abundance to highlight tissue-specific differences.

(C) Boxplots showing distribution of relative abundances (RA) from the 10 or fewer most abundant species detected in each cancer type, after removing low-prevalence and contaminant species.