Table 3.
Top 30 candidate SNPs selected from the GWAS (dominant model).
| Model | Rank | CHR | SNP | Position | p | Related Gene | Genotype (Patients) | Phenotype (Mean) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A/A | A/B | B/B | A/A | A/B | B/B | |||||||
| Dominant | 1 | 6 | kgp11947181 | 139582822 | 1.592 × 10−8 * | 0 | 2 | 417 | NA | 3.176 | 0.746 | |
| Dominant | 2 | 9 | 9:133013640 | 130251361 | 1.730 × 10−8 * | 0 | 2 | 417 | NA | 3.118 | 0.746 | |
| Dominant | 3 | 10 | rs763315292 | 119912126 | 3.807 × 10−8 * | SEC23IP | 0 | 3 | 416 | NA | 2.62 | 0.744 |
| Dominant | 4 | 6 | 6:80456944 | 79747227 | 1.223 × 10−7 | 0 | 4 | 415 | NA | 2.434 | 0.742 | |
| Dominant | 5 | 7 | 7:118263373 | 118623319 | 2.066 × 10−7 | 0 | 2 | 417 | NA | 2.953 | 0.747 | |
| Dominant | 6 | 10 | rs77717582 | 126393947 | 4.341 × 10−7 | 0 | 23 | 396 | NA | 1.411 | 0.72 | |
| Dominant | 7 | 1 | rs755431252 | 175365091 | 4.979 × 10−7 | TNR | 0 | 3 | 416 | NA | 2.677 | 0.744 |
| Dominant | 8 | 13 | 13:88770953 | 88118698 | 5.634 × 10−7 | 0 | 4 | 415 | NA | 2.109 | 0.745 | |
| Dominant | 9 | 2 | rs63751260 | 47403309 | 0.000001091 | MSH2 | 0 | 2 | 416 | NA | 2.883 | 0.749 |
| Dominant | 10 | 19 | rs146815072 | 32830639 | 0.000001368 | SLC7A9 | 0 | 4 | 415 | NA | 2.289 | 0.743 |
| Dominant | 11 | 5 | rs145778277 | 161311253 | 0.0000014 | GABRB2 | 0 | 13 | 406 | NA | 1.516 | 0.734 |
| Dominant | 12 | 18 | 18:3452222 | 3452225 | 0.000001471 | TGIF1 | 0 | 2 | 415 | NA | 2.859 | 0.75 |
| Dominant | 13 | 9 | GSA-rs10967750 | 27166161 | 0.000001495 | TEK | 0 | 5 | 414 | NA | 1.993 | 0.743 |
| Dominant | 14 | 19 | 19:12311461 | 12200646 | 0.000001562 | LOC100289333 | 1 | 9 | 408 | 2.471 | 1.537 | 0.738 |
| Dominant | 15 | 4 | JHU_4.166326986 | 165405835 | 0.000001738 | CPE | 3 | 54 | 362 | 0.942 | 1.079 | 0.708 |
| Dominant | 16 | 13 | 13:77841745 | 77267610 | 0.000002003 | MYCBP2 | 0 | 4 | 412 | NA | 2.031 | 0.747 |
| Dominant | 17 | 6 | rs192596782 | 155305908 | 0.000002575 | TFB1M | 0 | 3 | 413 | NA | 2.397 | 0.745 |
| Dominant | 18 | 3 | rs117341459 | 39630484 | 0.00000258 | 0 | 4 | 415 | NA | 2.144 | 0.744 | |
| Dominant | 19 | 18 | rs4632226 | 3989188 | 0.000002665 | DLGAP1,DLGAP1-AS4 | 1 | 27 | 390 | 0.179 | 1.287 | 0.722 |
| Dominant | 20 | 5 | kgp5717569 | 172042597 | 0.0000033 | STK10 | 1 | 31 | 386 | 2.125 | 1.136 | 0.725 |
| Dominant | 21 | 8 | GSA-rs147608943 | 30052419 | 0.000003361 | 0 | 5 | 414 | NA | 1.955 | 0.743 | |
| Dominant | 22 | 8 | 8:40320989 | 40463470 | 0.000003413 | 0 | 4 | 414 | NA | 2.163 | 0.739 | |
| Dominant | 23 | 3 | kgp2760268 | 26300600 | 0.000003538 | 0 | 3 | 416 | NA | 2.323 | 0.747 | |
| Dominant | 24 | 1 | kgp15630468 | 18045740 | 0.000003604 | 0 | 12 | 407 | NA | 1.479 | 0.737 | |
| Dominant | 25 | 1 | kgp15515856 | 47636211 | 0.000004042 | 0 | 8 | 411 | NA | 1.59 | 0.742 | |
| Dominant | 26 | 3 | 3:40166299 | 40124808 | 0.00000439 | MYRIP | 0 | 2 | 415 | NA | 2.646 | 0.75 |
| Dominant | 27 | 3 | 3:40027538 | 39986047 | 0.000004617 | MYRIP | 0 | 2 | 417 | NA | 2.646 | 0.749 |
| Dominant | 28 | 3 | 3:149817230 | 150099443 | 0.000004786 | 0 | 4 | 415 | NA | 2.075 | 0.745 | |
| Dominant | 29 | 19 | 19:12306462 | 12195647 | 0.000005029 | LOC100289333 | 1 | 14 | 404 | 2.471 | 1.345 | 0.733 |
| Dominant | 29 | 19 | 19:12352578 | 12241763 | 0.000005029 | 1 | 14 | 404 | 2.471 | 1.345 | 0.733 | |
Model, the genetic model in which the GWAS selected the candidate SNPs; CHR, chromosome number; Related gene, the gene that is closest to the SNP location; A/A, each SNP’s minor allele is homozygous; A/B, each SNP’s major allele is heterozygous; B/B, each SNP’s major allele is homozygous; NA, not available; * p < 5 × 10−8.