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. 2022 Sep 27;14(19):4692. doi: 10.3390/cancers14194692

Table 4.

Top 30 candidate SNPs selected from the GWAS (recessive model).

Model Rank CHR SNP Position p Related Gene Genotype (Patients) Phenotype (Mean)
A/A A/B B/B A/A A/B B/B
Recessive 1 8 rs1283671 107421459 7.698 × 10−11 * ANGPT1 5 87 327 2.375 0.873 0.703
Recessive 1 8 rs1283720 107460100 7.698 × 10−11 * ANGPT1 5 89 325 2.375 0.86 0.705
Recessive 3 9 GSA-rs72752701 125992274 3.814 × 10−8 * 2 50 367 3.011 0.776 0.743
Recessive 4 1 rs3917744 169608752 2.568 × 10−7 SELP 2 51 366 2.832 0.778 0.744
Recessive 5 12 rs11061996 1836333 2.672 × 10−7 CACNA2D4,LRTM2 2 47 370 2.774 0.714 0.752
Recessive 6 3 rs61355450 117954317 3.039 × 10−7 2 36 381 2.869 0.786 0.744
Recessive 6 3 rs6798512 118019819 3.039 × 10−7 2 36 381 2.869 0.786 0.744
Recessive 6 12 GSA-rs117577524 30549638 3.039 × 10−7 2 27 390 2.869 0.794 0.744
Recessive 9 13 rs9529111 66652839 4.469 × 10−7 PCDH9 19 131 269 1.426 0.672 0.752
Recessive 10 8 rs4620259 108979439 5.146 × 10−7 5 74 340 2.175 0.828 0.722
Recessive 11 16 rs74007038 6785856 6.499 × 10−7 RBFOX1 5 79 335 2.076 0.781 0.733
Recessive 12 19 rs75017760 8940941 0.000001066 MUC16 2 64 353 2.883 0.708 0.755
Recessive 13 1 1:118813000 118270377 0.000001725 2 39 378 2.917 0.805 0.741
Recessive 14 10 rs10749151 114017465 0.000001958 7 105 307 1.833 0.704 0.752
Recessive 15 12 rs1554080 128183013 0.000001979 5 70 344 1.814 0.701 0.754
Recessive 16 14 kgp19644675 100077596 0.000002605 EVL 5 57 357 1.927 0.851 0.727
Recessive 17 6 rs17059990 99980179 0.000003439 MCHR2 2 65 352 2.817 0.866 0.726
Recessive 18 11 rs10501687 88799011 0.000003562 GRM5 22 159 237 1.307 0.768 0.7
Recessive 19 18 rs117231913 79691289 0.000003767 CTDP1 3 55 361 2.421 0.693 0.754
Recessive 20 2 rs11692586 134159434 0.00000408 11 102 306 1.593 0.751 0.73
Recessive 21 21 rs2834573 34668083 0.000004617 2 93 324 2.646 0.696 0.764
Recessive 22 16 rs75384045 55308868 0.000005399 3 52 364 2.242 0.85 0.732
Recessive 23 2 2:42166453 41939313 0.000006107 C2orf91 35 162 220 1.168 0.74 0.702
Recessive 24 6 kgp3351958 122754906 0.00000622 2 36 380 2.838 0.709 0.751
Recessive 25 6 kgp17238235 27175279 0.000007322 4 85 330 1.919 0.795 0.734
Recessive 26 12 12:132932218 132355632 0.00000773 1 20 395 3.509 0.78 0.743
Recessive 27 3 rs73184492 189405146 0.000008219 1 53 364 3.509 0.939 0.718
Recessive 27 18 rs989644 4231203 0.000008219 DLGAP1 1 49 368 3.509 0.784 0.742
Recessive 27 19 rs112363595 56660873 0.000008219 1 18 399 3.509 0.707 0.748
Recessive 30 8 rs4734909 91861390 0.000009082 13 120 286 1.467 0.656 0.768

Model, the genetic model in which the GWAS selected the candidate SNPs; CHR, chromosome number; Related gene, the gene that is closest to the SNP location; A/A, each SNP’s minor allele is homozygous; A/B, each SNP’s major allele is heterozygous; B/B, each SNP’s major allele is homozygous; * p < 5 × 10−8.