Table 5.
Top 20 candidate genes selected from gene-based analysis.
| Model | Rank | CHR | Gene Start Position | Gene Stop Position | Gene | nSNPs | Z Statistic | p | P a |
|---|---|---|---|---|---|---|---|---|---|
| Additive | 1 | 12 | 7945108 | 8063744 | SLC2A14 | 30 | 4.6313 | 1.8167 × 10−6 | 0.035151328 * |
| Additive | 2 | 8 | 108241721 | 108530283 | ANGPT1 | 24 | 4.4216 | 4.8995 × 10−6 | 0.094800426 |
| Additive | 3 | 12 | 1909433 | 1965918 | LRTM2 | 19 | 4.1283 | 0.000018275 | 0.353602975 |
| Additive | 4 | 6 | 170131718 | 170201680 | ERMARD | 4 | 3.978 | 0.000034747 | 0.672319703 |
| Additive | 5 | 20 | 1141205 | 1186059 | TMEM74B | 8 | 3.9518 | 0.000038784 | 0.750431616 |
| Additive | 6 | 17 | 39113968 | 39163387 | KRT40 | 7 | 3.938 | 0.000041089 | 0.795031061 |
| Additive | 7 | 17 | 19102674 | 19145839 | AC106017.1 | 2 | 3.8561 | 0.000057607 | 1 |
| Additive | 8 | 7 | 112439202 | 112599971 | C7orf60 | 5 | 3.8481 | 0.000059519 | 1 |
| Additive | 9 | 1 | 169538087 | 169619431 | SELP | 21 | 3.7461 | 0.000089799 | 1 |
| Additive | 10 | 17 | 39094669 | 39143144 | KRT39 | 5 | 3.7175 | 0.00010059 | 1 |
| Additive | 11 | 17 | 39129686 | 39170385 | KRTAP3-3 | 6 | 3.7019 | 0.00010702 | 1 |
| Additive | 12 | 1 | 245113007 | 245310466 | EFCAB2 | 26 | 3.6928 | 0.00011092 | 1 |
| Additive | 13 | 3 | 50106341 | 50176454 | RBM5 | 4 | 3.6532 | 0.00012949 | 1 |
| Additive | 14 | 1 | 60338980 | 60412462 | CYP2J2 | 2 | 3.6525 | 0.00012986 | 1 |
| Additive | 15 | 1 | 93625476 | 93764287 | CCDC18 | 6 | 3.6329 | 0.00014014 | 1 |
| Additive | 16 | 13 | 75838808 | 76076250 | TBC1D4 | 42 | 3.6025 | 0.00015758 | 1 |
| Additive | 17 | 2 | 128828774 | 128973251 | UGGT1 | 6 | 3.5918 | 0.00016422 | 1 |
| Additive | 18 | 5 | 32669176 | 32811819 | NPR3 | 19 | 3.5168 | 0.00021839 | 1 |
| Additive | 19 | 1 | 54477347 | 54539177 | TMEM59 | 3 | 3.5143 | 0.00022045 | 1 |
| Additive | 20 | 6 | 169837307 | 170122159 | WDR27 | 15 | 3.4629 | 0.00026718 | 1 |
| Dominant | 1 | 15 | 41454923 | 41542941 | EXD1 | 5 | 4.3882 | 5.7145 × 10−6 | 0.108884083 |
| Dominant | 2 | 1 | 212983483 | 213040991 | C1orf227 | 5 | 3.9154 | 0.000045129 | 0.859887966 |
| Dominant | 3 | 17 | 28236218 | 28455470 | EFCAB5 | 10 | 3.876 | 0.000053086 | 1 |
| Dominant | 4 | 20 | 9498036 | 9839689 | PAK7 | 86 | 3.6046 | 0.00015634 | 1 |
| Dominant | 5 | 18 | 28936740 | 29014875 | DSG4 | 17 | 3.548 | 0.00019409 | 1 |
| Dominant | 6 | 19 | 12253879 | 12320064 | ZNF136 | 13 | 3.5248 | 0.00021191 | 1 |
| Dominant | 7 | 22 | 51041182 | 51086607 | ARSA | 19 | 3.4757 | 0.00025478 | 1 |
| Dominant | 8 | 16 | 47091614 | 47197908 | NETO2 | 6 | 3.4494 | 0.00028092 | 1 |
| Dominant | 9 | 1 | 213011597 | 213092705 | FLVCR1 | 9 | 3.4493 | 0.00028106 | 1 |
| Dominant | 10 | 5 | 171268553 | 171453877 | FBXW11 | 21 | 3.4178 | 0.00031566 | 1 |
| Dominant | 11 | 4 | 93198402 | 93245329 | RP11-9B6.1 | 3 | 3.3954 | 0.00034267 | 1 |
| Dominant | 12 | 5 | 171449077 | 171635390 | STK10 | 64 | 3.3934 | 0.00034512 | 1 |
| Dominant | 13 | 13 | 50466842 | 50530626 | SPRYD7 | 3 | 3.3782 | 0.00036482 | 1 |
| Dominant | 14 | 8 | 37680786 | 37727422 | BRF2 | 11 | 3.372 | 0.00037312 | 1 |
| Dominant | 15 | 18 | 54794293 | 54837531 | BOD1L2 | 15 | 3.3544 | 0.00039763 | 1 |
| Dominant | 16 | 12 | 116375711 | 116735143 | MED13L | 33 | 3.349 | 0.00040551 | 1 |
| Dominant | 17 | 22 | 51019114 | 51072409 | MAPK8IP2 | 25 | 3.3244 | 0.00044301 | 1 |
| Dominant | 18 | 12 | 55503465 | 55544586 | OR9K2 | 7 | 3.2881 | 0.00050434 | 1 |
| Dominant | 19 | 19 | 57301445 | 57372096 | PEG3 | 14 | 3.2739 | 0.00053034 | 1 |
| Dominant | 20 | 13 | 77598792 | 77921185 | MYCBP2 | 28 | 3.2397 | 0.00059826 | 1 |
| Recessive | 1 | 12 | 7945108 | 8063744 | SLC2A14 | 30 | 4.467 | 3.9655 × 10−6 | 0.073841576 |
| Recessive | 2 | 8 | 108241721 | 108530283 | ANGPT1 | 24 | 4.2961 | 8.6923 × 10−6 | 0.161859318 |
| Recessive | 3 | 12 | 1909433 | 1965918 | LRTM2 | 19 | 4.2181 | 0.000012317 | 0.229354857 |
| Recessive | 4 | 20 | 1141205 | 1186059 | TMEM74B | 8 | 3.9541 | 0.000038414 | 0.715307094 |
| Recessive | 5 | 17 | 39113968 | 39163387 | KRT40 | 7 | 3.9425 | 0.000040318 | 0.750761478 |
| Recessive | 6 | 6 | 170131718 | 170201680 | ERMARD | 4 | 3.9412 | 0.000040543 | 0.754951203 |
| Recessive | 7 | 17 | 19102674 | 19145839 | AC106017.1 | 2 | 3.8099 | 0.000069518 | 1 |
| Recessive | 8 | 7 | 112439202 | 112599971 | C7orf60 | 5 | 3.8012 | 0.000071998 | 1 |
| Recessive | 9 | 1 | 169538087 | 169619431 | SELP | 21 | 3.7878 | 0.000076002 | 1 |
| Recessive | 10 | 2 | 128828774 | 128973251 | UGGT1 | 6 | 3.7536 | 0.000087158 | 1 |
| Recessive | 11 | 13 | 75838808 | 76076250 | TBC1D4 | 42 | 3.7231 | 0.000098378 | 1 |
| Recessive | 12 | 17 | 39129686 | 39170385 | KRTAP3-3 | 6 | 3.7097 | 0.00010375 | 1 |
| Recessive | 13 | 17 | 39094669 | 39143144 | KRT39 | 5 | 3.7068 | 0.00010496 | 1 |
| Recessive | 14 | 3 | 50106341 | 50176454 | RBM5 | 4 | 3.6936 | 0.00011057 | 1 |
| Recessive | 15 | 1 | 60338980 | 60412462 | CYP2J2 | 2 | 3.6468 | 0.00013276 | 1 |
| Recessive | 16 | 16 | 85703690 | 85804735 | C16orf74 | 11 | 3.5785 | 0.00017279 | 1 |
| Recessive | 17 | 12 | 1881123 | 2048002 | CACNA2D4 | 41 | 3.5256 | 0.00021126 | 1 |
| Recessive | 18 | 1 | 93625476 | 93764287 | CCDC18 | 6 | 3.5227 | 0.00021358 | 1 |
| Recessive | 19 | 3 | 47249516 | 47344941 | KIF9 | 3 | 3.4581 | 0.00027197 | 1 |
| Recessive | 20 | 6 | 169837307 | 170122159 | WDR27 | 15 | 3.454 | 0.00027618 | 1 |
Model, the genetic model in which candidate genes were selected by analysis; CHR, chromosome number; nSNPs, the number of SNPs annotated to the gene; Z Statistic, gene-based test statistic; p a, adjusted p value for multiple testing; *, significant association after conservative Bonferroni correction.