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. 2022 Oct 3;119(41):e2204758119. doi: 10.1073/pnas.2204758119

Fig. 5.

Fig. 5.

CM from obese adipocytes alters the angiogenic and invasive profile of dormant BC cells. Expression of proangiogenic factors (A) and Tsp-1 (B; Student's t test, *P < 0.05, **P < 0.001) in ObAdCM-treated MDA-MB-436P and MCF-7 BC cells. ObAdCM promoted EC recruitment by ER− (MDA-MB-436P; ***P < 0.0001; C) and ER+ (MCF-7; *P < 0.05; D) BC cells. IL-6 neutralization inhibited ObAdCM-stimulated EC recruitment by BC cells (E; *P < 0.05). ObAdCM promoted invasion of MDA-MB-436P and MCF-7 cells and IL-6 neutralization inhibited ObAdCM-stimulated invasion by BC cells (F and G; Student's t test, *P < 0.05). All error bars indicate mean ± SEM.