Table 1.
Autophagy inhibitors enhance the efficacy of immunotherapy.
| Autophagy Inhibitor | Targets | Immunotherapy | Tumor Types | Refs. |
|---|---|---|---|---|
| SB02024 | Vps34 | Anti-PD-L1 and Anti-PD-1 | Melanoma, CRC | [148] |
| SAR405 | Vps34 | Anti-PD-L1 and Anti-PD-1 | Melanoma, CRC | [148] |
| Autophinib | Vps34 | TNFα | Various cancers | [138] |
| Hydroxychloroquine | Lysosomes, PPT1 | anti-PD-1 | Melanoma | [149] |
| LipHCQa | Lysosomes | Shikonin-induced ICD | Colon cancer | [152] |
| Chloroquine | Lysosomes | anti-PD1/CTLA4 HDIL-2 |
Pancreatic cancer, metastatic liver cancer, renal cell carcinoma | [55,110,151] |