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. 2022 Oct 6;11(19):3146. doi: 10.3390/cells11193146

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The retinal-like epigenetic modification enables RPE cells to perform better in photoreceptor induction. (a) Heatmap showing the differently methylated genes with the treatment of 5F or 5FA on HDF at D10. (b,c) Example of a genome browser view of DNA methylation profiles of NRL (b) and OLFM3 (c) in HDF-derived samples and RPE-derived samples. Each track shows the percent methylation of individual CpGs. (d) Heatmap showing the differently methylated genes in H-CiPCs, R-CiPCs, and fRetina. (e) Pie plot showing the distribution of methylation changes in H-CiPCs and R-CiPCs at gene promoters upon 5F treatment. (f) Heatmap showing the differently methylated genes associated with neurogenesis in H-CiPCs and R-CiPCs. (g) Example of a genome browser view of DNA methylation profiles of OTX2 and NRL gene in HDF, RPE, and fRetina. Each track shows the percent methylation of individual CpGs.