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Structure of the MUC1 heterodimeric complex. MUC1 is translated as a single polypeptide that includes a signal sequence for membrane localization and an extended region of O-glycosylated 20 aa tandem repeats (TRs). MUC1 also includes a SEA domain and a transmembrane (TM) domain. Autoproteolysis within the SEA domain results in the generation of MUC1 N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits that form a non-covalent complex. Figure modified from Kufe [9].
