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MUC1-C activates JAK1→STAT3 signaling in an auto-inductive loop (NODE 3). As found for TAK1 in the NF-κB pathway, the MUC1-C/CD CQC motif binds to JAK1. In addition, like NF-κB p65, the MUC1-C/CD SRM functions as a site for direct binding to the STAT3 DBD and for JAK1-mediated pSTAT3 activation [82]. In turn, pSTAT3 induces MUC1 expression in another auto-inductive inflammatory circuit that parallels the node driving MUC1-C→NF-κB signaling.
