Figure 5.

Tumor suppressor genes (TSG) signature. (A) Hierarchical clustering expression heatmap for expression values of the TSG signature; (B) Kaplan–Meier curves representing CRPC-free survival (CRPC-FS) and overall survival (OS) according to TSG signature and forest plot representing the multivariate analysis for OS; (C) forest plots representing the univariate and multivariate analysis of the individual genes of the TSG signature as continuous variables for CRPC-FS and OS. The reciprocal of the hazard ratio (HR) and the associated confidence interval (CI) were calculated; (D) Kaplan–Meier curves representing CRPC-FS and OS according to low expression of two out of the three TSG, and forest plots representing the multivariate analysis. Expression levels were segregated into tertiles to establish the cut-offs. LDH: lactate dehydrogenase.