TABLE 4.
Cox proportional hazards model reporting crude hazard ratios and adjusted hazards ratios of overall survival (n = 3848) a
| Characteristic | Crude HR | (95% CI) | Adjusted HR | (95% CI) |
|---|---|---|---|---|
| Age at diagnosis (in years) b | ||||
| 1.02 | (1.01–1.02) | 1.02 | (1.01–1.03) | |
| FIGO stage b | ||||
| Stage IIIC | Reference | Reference | ||
| Stage IV | 1.33 | (1.23–1.44) | 1.35 | (1.17–1.56) |
| Tumor grade | ||||
| Grade 1 | Reference | Reference | ||
| Grade 2 | 1.51 | (1.21–1.89) | 1.33 | (1.06–1.67) |
| Grade 3 | 1.36 | (1.11–1.66) | 1.21 | (0.99–1.48) |
| Unknown | 1.57 | (1.28–1.92) | 1.25 | (1.02–1.54) |
| Treatment approach | ||||
| PCS | Reference | Reference | ||
| NACT‐ICS | 1.56 | (1.44–1.69) | 1.57 | (1.44–1.71) |
| Residual disease after debulking b | ||||
| No macroscopic disease | Reference | Reference | ||
| ≤1 cm | 1.65 | (1.53–1.78) | 2.15 | (1.90–2.42) |
| >1 cm | 2.86 | (2.58–3.19) | 4.24 | (3.53–5.10) |
| Splenectomy | ||||
| No | Reference | Reference | ||
| Yes | 0.89 | (0.71–1.12) | 0.97 | (0.77–1.22) |
Abbreviations: CI, confidence interval; HR, hazard ratio; NACT‐ICS, neoadjuvant chemotherapy followed by interval cytoreductive surgery; PCS, primary cytoreductive surgery.
a
An additional 63 patients were excluded respectively from multivariable Cox regression analysis with reference to Figure 1, since these patients had unknown data on recurrence data or one of the other variables included in the multivariable model.
b
These variables (age at diagnosis, FIGO stage and residual disease after debulking) are time‐varying covariates and were included in the multivariable model as such.