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. 2022 Oct 3;119(41):e2210849119. doi: 10.1073/pnas.2210849119

Fig. 1.

Fig. 1.

Tmc1 mutations that reduce MET channel conductance in OHCs. (A) Control Tmc1+/+;Tmc2−/− single-channel currents in response to a step displacement (ΔX, Upper) of the hair bundle, ensemble average of 50 stimuli below. (B) Amplitude histograms of records on left, mean −6.7 ± 0.3 pA. (C) Tmc1 D528N/D528N;Tmc2−/− single-channel currents for 100-nm bundle displacement, ensemble average of 30 stimuli below. (D) Amplitude histograms of records on left, mean −4.4 ± 0.3 pA. (E) Tmc1 E520Q/E520Q;Tmc2−/− single-channel currents for 100-nm bundle displacement, ensemble average of 60 stimuli below. (F) Amplitude histograms of records on left, mean −4.3 ± 0.3 pA. Both mutations produce ∼35% amplitude reduction. Holding potential −84 mV; all OHCs located at d = 0.3 in P5 mice.