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. 2022 Oct 3;119(41):e2210849119. doi: 10.1073/pnas.2210849119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 2. — MET channel currents in IHCs from Tmc1 mutant mice. (A) Tmc1^+/−;Tmc2^−/− single-channel currents for bundle displacements (Top) and ensemble average for 100 stimuli (Middle). Amplitude histogram (Bottom) gives single-channel current of −6.5 pA. (B) Tmc1^−/−;Tmc2^+/+ single-channel currents for bundle displacements (Top) and ensemble average for 50 stimuli (Middle). Amplitude histogram (Bottom) gives single-channel current of −4.9 pA, indicating that TMC2 channels have smaller current amplitudes than TMC1 in A. (C) Tmc1 M412K/M412K;Tmc2^−/− single-channel currents for bundle displacements (Top) and ensemble average for 100 stimuli (Middle; taken from ref. 41). Amplitude histogram (Bottom) gives a single-channel current of Tmc1 M412K/M412K (Beethoven) as −6.3 pA, no different from control in A. Holding potential: −84 mV. All IHCs were located at d = 0.2 in P4 to P5 mice.