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Single MET channel currents in apical OHCs of Tmie knockouts. (A) Tmc1+/+;Tmie−/− single-channel currents in response to a 100-nm step displacement of the hair bundle (Top), ensemble average of 50 stimuli shown below. (B) Amplitude histograms of records on left, mean −5.0 pA. (C) Tmc1 D528N/D528N;Tmie−/− single-channel currents for 100-nm bundle displacement, ensemble average of 30 stimuli below. (D) Amplitude histograms of records on left, give mean −3.4 pA; holding potential −84 mV.
