Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 3;119(41):e2206684119. doi: 10.1073/pnas.2206684119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

PMC Copyright notice

Fig. 5. — Bioinformatic analysis of gene expression of hMSCs on different TPMS scaffolds. (A) Venn diagram illustration of the DEGs between the TPMS scaffolds (G2, G4, and G6) and the conventional truss scaffold (G0). (B–D) Volcano plots of transcriptomic analysis of DEGs in (B) G2 versus G0, (C) G4 versus G0, and (D) G6 versus G0. (E) Up-regulated enriched Kyoto Encyclopedia of Genes and Genomes pathways of G6 versus G0. (F) Heatmap evaluation of DEGs involved in ECM–receptor interaction, cell adhesion molecule, MAPK, and proinflammatory signaling pathways. (G) Relative messenger RNA expression evaluation of targeted genes via qRT-PCR. (H) Schematic illustration of potential integrin-mediated FAK and MAPK pathway activation mechanism of hMSCs’ osteogenic differentiation and angiogenic paracrine response on the hyperboloidal structure.