|
g
|
growth rate of cell volume |
|
ρ
|
burst frequency before replication |
|
κρ
|
burst frequency after replication |
|
B
|
proportionality constant
for the mean burst size |
|
β
|
degree of balanced biosynthesis |
|
d
|
degradation rate of the gene product |
|
N
|
total number of effective cell
cycle stages |
|
N
0
|
number of effective cell cycle stages before replication |
|
α
0
|
strength of size control before replication |
|
α
1
|
strength
of size control after replication |
|
a
|
proportionality constant for the
transition rate between stages |
| derived parameters |
meaning |
|
T ≈ log(2)/g
|
mean cell cycle duration |
|
f = 1/T
|
cell cycle
frequency |
|
deff = d + (log 2)f
|
effective decay rate of the gene product |
|
η = d/f
|
ratio of the degradation rate to the cell cycle frequency |
|
v
k
|
mean cell volume at stage k
|
|
q
k
|
transition rate from stage k to the next in the mean-field model |
|
B
k
|
mean burst size at stage k in the mean-field model |
|
ρ
k
|
burst
frequency at stage k in the mean-field model |
|
w = log2(vN0 + 1/v1) |
proportion
of cell cycle duration before replication |
