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. 2022 Sep 30;12:954512. doi: 10.3389/fonc.2022.954512

Table 1.

NADnet pathway reactions to gene, enzyme, and Factor mappings information.

No. Reaction ID Gene Enzyme name EC Reaction Factor
1 J1 TDO2, IDO2, IDO1 Tryptophan 2,3-dioxygenase 1.13.11.11 L-Tryptophan + O2 = N-Formyl-L-kynurenine F1
2 J2 AFMID Formylkynurenine formamidase 3.5.1.9 N-Formyl-L-kynurenine + H2O = Formate + L-Kynurenine F2
3 J3 KMO Kynurenine 3-hydroxylase 1.14.13.9 L-Kynurenine + NADPH + H+ + O2 = 3-Hydroxy-L-kynurenine + NADP+ + H2O F3
4 J4 KYNU Kynureninase 3.7.1.3 3-Hydroxy-L-kynurenine + H2O = 3-Hydroxyanthranilate + L-Alanine F4
5 J5 HAAO 3-Hydroxyanthranilate 3,4-dioxygenase 1.13.11.6 3-Hydroxyanthranilate + O2 = 2-Amino-3-carboxymuconate semialdehyde → Quinolinate F5
6 J6 QPRT Quinolinate phosphoribosyltransferase 2.4.2.19 Quinolinate + PRPP = NMN + PPi + CO2 F6
7 J7 NMNAT1, NMNAT2, NMNAT3 NMN adenylyltransferase 2.7.7.1 NaMN + ATP = NaAD+ + PPi F7
8 J8 NMNAT1, NMNAT2, NMNAT3 NMN adenylyltransferase 2.7.7.1 NMN + ATP = NAD+ + PPi F8
9 J9 NADSYN1 NAD+ synthetase (glutamine-hydrolyzing) 6.3.5.1 NaAD+ + ATP + L-Gln + H2O = NAD+ + AMP + PPi + L-Glu F9
10 J10 NADSYN1 NAD+ synthetase (ammonia-dependent) 6.3.1.5 NaAD+ + ATP + NH3 = NAD+ + AMP + PPi F10
11 J11 NADK NAD+ kinase 2.7.1.23 NAD+ + ATP = NADP+ + ADP F11
12 J12 BST1, CD38 NAD+ glycohydrolase 3.2.2.5 NAD+ + H2O = Nicotinamide + ADP-ribose F12
13 J13 BST1, CD38 NAD(P)+ nucleosidase 3.2.2.6 NAD(P)++ H2O = Nicotinamide + ADP-ribose(2¢-phosphate) F13
14 J14 PARP1 Poly (ADP-ribose) polymerase 2.4.2.30 NAD+ + (ADP-ribose) n = Nicotinamide + (ADP-ribose) n+1 F14
15 J15 ART3, ART4, ART5, SIRT6 Mono ADPribosyltransferase 2.4.2.31 NAD ++ L-Arg = Nicotinamide + N(2)-(ADP-ribosyl)-L-Arg F15
16 J16 ENPP1, ENPP3 NAD+ pyrophosphatase 3.6.1.22 NAD+ + H2O = AMP + NMN F16
17 J17 NAMPT Nicotinamide phosphoribosyltransferase 2.4.2.12 Nicotinamide + PRPP = NMN + PPi F17
18 J18 NT5E, NT5C1A, NT5C2 5’-Nucleotidase 3.1.3.5 NMN + H2O = Nicotinamide riboside + P F18
19 J19 PNP Nicotinamide nucleoside phosphorylase 2.4.2.1 Nicotinamide riboside + P = Nicotinamide + R-1-P F19
20 J20 NMRK1 Ribosylnicotinamide kinase 2.7.1.22 ATP + Nicotinamide riboside = ADP + NMN F20
21 J22 NAPRT Nicotinate phosphoribosyltransferase 2.4.2.11 Nicotinate + PRPP = NaMN + PPi F22