TABLE 2.
Transplacental transmission of pneumococcal serotype antibodies in term newborns
| Parameter | Value in serotype:
|
||||
|---|---|---|---|---|---|
| 1 (n = 15) | 3 (n = 15) | 6B (n = 15) | 9V (n = 15) | 14 (n = 14) | |
| Mothers | |||||
| GMa (μg/ml) | 1.73 | 0.94 | 2.09 | 1.30 | 3.21 |
| 95% CI | 1.28–4.14 | 0.44–2.48 | 1.63–5.00 | 0.92–3.44 | 1.95–6.98 |
| Infants | |||||
| GM (μg/ml) | 1.38 | 1.03 | 1.60 | 0.98 | 3.09 |
| 95% CI | 0.87–3.53 | 0.17–3.25 | 0.99–4.00 | 0.63–2.59 | 2.24–5.76 |
| P valueb | 0.0151 | 0.5995 | 0.0031 | 0.0012 | 0.9515 |
| Ratioc (mean % ± SD) | 83 ± 23 | 116 ± 44 | 79 ± 20 | 77 ± 18 | 99 ± 24 |
a
GM, geometric mean.
b
P value represents the comparison of maternal and infant antibody concentrations (Wilcoxon signed-rank test).
c
There was a high correlation (r ≥ 0.884; P < 0.0001) between maternal and term-newborn antibody concentrations for the serotypes tested (least-squares linear regression).