TABLE 6.

Median values for immune parameters, by diagnosis of participants with monomicrobial BSI

Immune parameter by cell population	No. of patients with:			% Cell population positive, by infection status			P valuea
	Type I infection	Bacterial infection	Negative blood culture	Type I infection	Bacterial infection	Negative blood culture
All lymphocytes
% CD3− NK	24	5	24	2.6	5.1	1.2	0.021
% IL-6+	23	5	24	3.6	0.2	6.5	0.019
% IL-6+ IFN-γ+	23	5	24	0.2	0.0	0.2	0.030
% IL-10+	23	5	24	7.6	0.8	6.9	0.009
CD3+ lymphocytes
% IL-4+	24	5	24	3.0	0.2	3.4	0.034
% IL-6+	23	5	24	1.6	0.3	0.8	0.047
% IFN-γ+	24	5	24	33.6	12.9	17.3	0.005
CD3+ CD8+ lymphocytes
% IL-8+	23	5	24	4.3	1.1	7.5	0.004
% IFN-γ+	23	5	24	35.9	10.9	27.0	0.007
CD19+ lymphocytes
% IL-4+	21	4	21	0.9	0.0	0.2	0.022
Monocytes (by scatter)
% CD14+	24	5	24	8.1	4.6	17.3	0.027
% IL-4+ IL-12+	24	5	24	0.4	0.0	0.1	0.019
% TNF-α+	23	5	23	0.4	0.0	0.6	0.004
% TNF-α+ IFN-γ+	23	5	23	0.2	0.0	0.3	0.008

^aP values are for three-way comparisons among participants with type I infections, bacterial infections, or negative blood cultures for each described variable. For example, for the percentage of all lymphocytes producing IL-6 in the peripheral blood samples of patients with type I organisms in their bloodstream (3.6%) compared to the percentage of all lymphocytes producing IL-6 in the peripheral blood samples of patients with bacteria in their bloodstream (0.2%) compared to the percentage of all lymphocytes producing IL-6 in the peripheral blood samples of patients with no organism grown from their bloodstream (6.5%), the P value is 0.019 (Kruskal-Wallis chi square approximation analysis).