TABLE 4.
Synthesis of IL-2 by T-cell subsets
| Phenotype | T cells synthesizing IL-2a
|
|||||
|---|---|---|---|---|---|---|
| Control subjects
|
MF
|
SS
|
||||
| % | Count/μl | % | Count/μl | % | Count/μl | |
| Total CD3+ | 35.0 (5.5) | 466 (58) | 40.2 (4.4) | 343 (57) | 35.0 (6.9) | 493 (108) |
| CD3+ CD7+ | 35.2 (4.6) | 414 (54) | 38.7 (4.3) | 303 (52) | 32.0 (4.3) | 134 (51)b |
| CD3+ CD7− | 42.5 (5.7) | 49 (8) | 41.9 (4.6) | 39 (7) | 42.2 (7.2) | 426 (121)b |
| CD3+ CD4+ | 49.9 (5.4) | 383 (58) | 24.0 (4.7) | 236 (49) | 28.6 (6.3) | 561 (148)c |
| CD3+ CD8+ | 13.3 (2.3) | 53 (8) | 37.6 (6.5)d | 192 (49)d | 17.9 (2.9) | 22 (7)c |
a
Figures represent means ± standard errors of the mean (in parentheses).
b
There were significantly lower numbers of IL2+ CD7+ T cells and significantly higher numbers of IL2+ CD7− T cells in patients with SS than in patients with MF and controls.
c
There were significantly higher numbers of IL2+ CD4+ T cells and significantly lower numbers of IL2+ CD8+ T cells in patients with SS than in patients with MF.
d
Mean percentages and numbers of IL2+ CD8+ T cells of patients with MF were significantly higher than those of controls.