Table 3.

Retinal nerve fiber layer thickness at the peripapillary level recorded at baseline and at 3 and 12 months of follow up in patients with obstructive sleep apnea undergoing continuous positive airway pressure treatment.

	Baseline	3 Months	12 Months	P* Raw	P** Adjusted (1) (2) (3)
RNFL_G	97.98 (±9.12)	99.51 (±9.55)	98.96 (±9.02)	<0.001	<0.001 0.012 0.535
RNFL_T	72.94 (±12.67)	74.24 (±13.60)	73.69 (±12.61)	0.046	0.003 0.364 0.999
RNFL_ST	135.80 (±21.44)	136.04 (±21.83)	136.57 (±21.26)	0.581	NA
RNFL_SN	111.94 (±24.92)	114.37 (±25.12)	113.06 (±24.36)	0.014	0.004 0.170 0.215
RNFL_N	72.43 (±11.45)	74.43 (±11.63)	73.24 (±10.81)	0.001	0.001 0.392 0.137
RNFL_IN	101.94 (±20.31)	103.82 (±20.38)	103.94 (±20.25)	0.030	0.001 0.050 0.237
RNFL_IT	143.49 (±18.88)	144.82 (±20.31)	143.61 (±18.25)	0.135	NA

Data expressed as the mean (±standard deviation). P* raw: significance level obtained by repeated measures ANOVA or Friedman test (according to normality of data distribution). P** adjusted: adjusted significance level obtained through post-hoc tests for multiple comparisons: Bonferroni or Wilcoxon (according to normality of data distribution). (1) Baseline vs. 3 months. (2) Baseline vs. 12 months. (3) 3 months vs. 12 months. NA: Post-hoc test not applicable for P* greater than 0.1. Values in bold indicate p < 0.05. RNFL_G = retinal nerve fiber layer global, T = temporal, ST = superotemporal, SN = superonasal, N = nasal, IN = inferonasal, IT = inferotemporal.